Interplay Between CD3 and CD28 Signals and MEK Kinase 1 (MEKK1) May Mediate the by CD28 Signaling: p21-Activated Kinase (PAK) Activation of p21-CDC42/Rac-Activated Kinases
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MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42.
MEK kinases (MEKKs) 1, 2, 3 and 4 are members of sequential kinase pathways that regulate MAP kinases including c-Jun NH2-terminal kinases (JNKs) and extracellular regulated kinases (ERKs). Confocal immunofluorescence microscopy of COS cells demonstrated differential MEKK subcellular localization: MEKK1 was nuclear and in post-Golgi vesicular-like structures; MEKK2 and 4 were localized to disti...
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